Biophysical Studies of Respiratory Syncytial Virus II. Identification of Two Soluble Complement-Fixing Antigens of Respiratory Syncytial Virus
AUTOR(ES)
Forsyth, Ben R.
RESUMO
Forsyth, Ben R. (National Institute of Allergy and Infectious Diseases, Bethesda, Md.), Helen V. Coates, and Robert M. Chanock. Biophysical studies of respiratory syncytial virus. II. Identification of two soluble complement-fixing antigens of respiratory syncytial virus. J. Bacteriol. 91:1270–1276. 1966.—Column chromatography of concentrated preparations was used to separate two antigenic components from the “soluble complement-fixing (CF) antigen” of respiratory syncytial (RS) virus. These antigens, designated antigen A and antigen B, stimulated homologous but not heterologous CF antibodies. Only antigen A stimulated the production of neutralizing antibody in guinea pigs. There was a dissociation between the CF and neutralizing antibody responses of guinea pigs immunized with antigen A. The two antigens were shown to have different molecular size, density, and sensitivity to lipolytic agents. Both antigens appeared to be components of the RS viral particle. Serological studies demonstrated that both antigens were formed during RS virus infection of children and adults.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=316023Documentos Relacionados
- Biophysical Studies of Respiratory Syncytial Virus I. Density of Respiratory Syncytial Virus and Associated Complement-Fixing Antigens in a Cesium Chloride Density Gradient
- Density of Infectious Virus and Complement-Fixing Antigens of Two Rhinovirus Strains
- Stability of Rubella Complement-fixing Antigens
- An Investigation into the Use of Cardiolipin Antigens. II. Complement-Fixing Properties of Cardiolipin Wassermann Antigen*
- Complement-Fixing Antigens of Herpes Simplex Virus Types 1 and 2: Reactivity of Capsid, Envelope, and Soluble Antigens
