Biomimetic oxidation of carbamazepine with hydrogen peroxide catalyzed by a manganese porphyrin

AUTOR(ES)

Neves, Cláudia M. B., Simões, Mário M. Q., Domingues, Fernando M. J., Neves, M. Graça P. M. S., Cavaleiro, José A. S.

FONTE

Química Nova

DATA DE PUBLICAÇÃO

2012

RESUMO

This laboratory project is planned for an undergraduate chemistry laboratory in which students prepare a manganese porphyrin able to mimic the oxidative metabolism of carbamazepine, one of the most frequently prescribed drugs in the treatment of epilepsy. The in vitro oxidation of carbamazepine results in the formation of the corresponding 10,11-epoxide, the main in vivo metabolite. The reaction is catalyzed by manganese porphyrin in the presence of H2O2, an environmentally-friendly oxidant. Through this project students will develop their skills in organic synthesis, coordination chemistry, chromatographic techniques such as TLC and HPLC, UV-visible spectrophotometry, and NMR spectroscopy.

Documentos Relacionados

• Biomimetic hydrogen generation catalyzed by triironnonacarbonyl disulfide cluster
• Manganese(II) catalyzes the bicarbonate-dependent oxidation of amino acids by hydrogen peroxide and the amino acid-facilitated dismutation of hydrogen peroxide.
• Manganese Peroxidase-Dependent Oxidation of Glyoxylic and Oxalic Acids Synthesized by Ceriporiopsis subvermispora Produces Extracellular Hydrogen Peroxide
• Photoinduced oxidation of a water-soluble manganese(III) porphyrin
• Kinetics of the Decomposition of Hydrogen Peroxide Catalyzed by Ferric Ethylenediaminetetraacetate Complex