Biological activities of toxins A and B of Clostridium difficile.
AUTOR(ES)
Lyerly, D M
RESUMO
Examination of the biological activities of the two known toxins of Clostridium difficile revealed that one of the toxins (toxin A) elicited a hemorrhagic fluid response in rabbit intestinal loops and a positive fluid response in infant mice. The other toxin (toxin B) did not produce a significant fluid response in either model, although the toxin was more lethal in infant mice. Both toxins elicited erythematous and hemorrhagic skin reactions and increased vascular permeability in rabbit skin.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=351167Documentos Relacionados
- Purification and characterization of toxins A and B of Clostridium difficile.
- Differential cytotoxic effects of toxins A and B isolated from Clostridium difficile.
- Enzyme immunoassay for detection of antibody to toxins A and B of Clostridium difficile.
- Comparison of two toxins produced by Clostridium difficile.
- Molecular, immunological, and biological characterization of a toxin A-negative, toxin B-positive strain of Clostridium difficile.
