Biofilm production by multiresistant Corynebacterium striatumassociated with nosocomial outbreak

AUTOR(ES)

Souza, Cassius de, Faria, Yuri Vieira, Sant’Anna, Lincoln de Oliveira, Viana, Vanilda Gonçalves, Seabra, Sérgio Henrique, Souza, Mônica Cristina de, Vieira, Verônica Viana, Hirata Júnior, Raphael, Moreira, Lílian de Oliveira, Mattos-Guaraldi, Ana Luíza de

FONTE

Mem. Inst. Oswaldo Cruz

DATA DE PUBLICAÇÃO

2015-04

RESUMO

Corynebacterium striatum is a potentially pathogenic microorganism that causes nosocomial outbreaks. However, little is known about its virulence factors that may contribute to healthcare-associated infections (HAIs). We investigated the biofilm production on abiotic surfaces of multidrug-resistant (MDR) and multidrug-susceptible (MDS) strains of C. striatum of pulsed-field gel electrophoresis types I-MDR, II-MDR, III-MDS and IV-MDS isolated during a nosocomial outbreak in Rio de Janeiro, Brazil. The results showed that C. striatum was able to adhere to hydrophilic and hydrophobic abiotic surfaces. The C. striatum1987/I-MDR strain, predominantly isolated from patients undergoing endotracheal intubation procedures, showed the greatest ability to adhere to all surfaces. C. striatumbound fibrinogen to its surface, which contributed to biofilm formation. Scanning electron microscopy showed the production of mature biofilms on polyurethane catheters by all pulsotypes. In conclusion, biofilm production may contribute to the establishment of HAIs caused by C. striatum.

Documentos Relacionados

• Outbreak of nosocomial urinary tract infections caused by Serratia marcescens.
• Nosocomial Outbreak Due to a Multiresistant Strain of Pseudomonas aeruginosa P12: Efficacy of Cefepime-Amikacin Therapy and Analysis of β-Lactam Resistance
• Polymyxin B Nephrotoxicity and Efficacy against Nosocomial Infections Caused by Multiresistant Gram-Negative Bacteria
• Characterization of a Nosocomial Outbreak Caused by a Multiresistant Acinetobacter baumannii Strain with a Carbapenem-Hydrolyzing Enzyme: High-Level Carbapenem Resistance in A. baumannii Is Not Due Solely to the Presence of β-Lactamases
• Genome sequence of a multidrug-resistant Corynebacterium striatum isolated from bloodstream infection from a nosocomial outbreak in Rio de Janeiro, Brazil