Biodisponibilidade e atividade antineoplasica de um novo modificador da resposta biologica

AUTOR(ES)
DATA DE PUBLICAÇÃO

1996

RESUMO

The in vivo effects of the protein magnesium ammonium phospholinoleate-palmitoleate anhydride polymer, MAPA were investigated to understand some of its mechanistic aspects. Preliminary evaluation of the bioavailability of MAPA was carried out. A single dose of 750 mg/Kg was intraperitoneally (IP) administered to male Wistar rats. After preselected time periods magnesium ions (Mg) analysis were carried out in digested samples of plasma and target organs, by atomic absorption technique. The Mg was rapidly absorbed, the mean t1/2 was 5,3 h over this dose and the area under the curve (AUC) value was 255,9 mg/mL.h. The same profile for the Mg plasma concentration versus time was observed when different doses of MAPA were selected. However, different half-lives were obtained for each dose and the AUC was not proportional to the dose. These results indicate that the drug does not follow an one-compartment kinetic model. The effect of different doses of MAPA on the Walker-256 tumor was examined. Female Wistar rats were inoculated with the tumor cells, line A or subline Ar, in the subcutaneous (SC) dorso-lumbar region, at one or more simultaneous sites. Rats receiving one single SC inoculation of the tumor cells presented significant regressions only when low doses of MAPA were administered. No effects were observed in rats immunodepressed, suggesting that the protective mechanisms could be involved in the in vivo antitumoral activity of MAPA. It was also investigated the effect of different magnesium salts, Mg3(PO4)2 and NH4MgPO4, as models of MAPA over blood cell populations counts. The results suggested a possible role played by Mg in the activity of MAPA, as one of its major components.

ASSUNTO(S)

biodisponibilidade magnesio

ACESSO AO ARTIGO

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