Bioactive Insulin-Like Growth Factor-I in Obesity

AUTOR(ES)

Frystyk, J.

FONTE

The Endocrine Society

RESUMO

Context: In obesity, total IGF-I is not reduced to the degree predicted by low GH levels, and free IGF-I levels are normal to high. Total and free IGF-I may not reflect IGF-I biological activity because immunoassays cannot account for the modifying effects of IGF binding proteins on interactions between IGF-I and its receptor.

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