Bioactive dicaffeoylquinic acid derivatives from the root extract of Calea urticifolia
AUTOR(ES)
Mijangos-Ramos, Ivan Felipe, Zapata-Estrella, Hiatzy E., Ruiz-Vargas, Javier A., Escalante-Erosa, Fabiola, Gómez-Ojeda, Noemi, García-Sosa, Karlina, Cechinel-Filho, Valdir, Meira-Quintão, Nara L., Peña-Rodríguez, Luis M.
FONTE
Rev. bras. farmacogn.
DATA DE PUBLICAÇÃO
2018-06
RESUMO
ABSTRACT Calea urticifolia (Mill.) DC., Asteraceae, is a native plant of the Yucatan Peninsula used in traditional medicine to treat inflammation and pain. The bioassay-guided purification of the ethanol root extract allowed the isolation of the main bioactive metabolites, which were identified as an inseparable mixture of thymol (1) and 3-methyl-4-isopropylphenol (2), together with 3,4-O-dicaffeoylquinic acid methyl ester (3), 3,4-O-dicaffeoyl-epi-quinic acid methyl ester (4), 3,5-O-dicaffeoyl-epi-quinic acid methyl ester (5) and 3,5-O-dicaffeoylquinic acid (6). The results showed that the analgesic activity detected in the root extract of C. urticifolia could be attributed mainly to the mixture of 1 and 2 and to the novel 3,4-O-dicaffeoyl-epi-quinic acid methyl ester (4). Alternatively, the similarity on the antiinflammatory and antioxidant activities of the dicaffeoylquinic acid derivatives 3–5 suggests that the former might be related to their ability as radical scavengers.
Documentos Relacionados
- Bioactive derivatives obtained from lecanoric acid, a constituent of the lichen Parmotrema tinctorum (Nyl.) Hale (Parmeliaceae)
- Anticancer activity of Calea pinnatifida banks leaves crude extract and fractions
- Biogenic synthesis of silver nanoparticles from thyme extract for functionalization of a bioactive glass produced from rice husk ash
- RP-HPLC and LC–MS–MS determination of a bioactive artefact from Ipomoea pes-caprae extract
- Evaluation of trypanocidal activity from Calea uniflora (Heliantheae-Asteraceae) extracts