Bile salts and cholesterol in the pathogenesis of target cells in obstructive jaundice
Cooper, Richard A.
Free cholesterol is in rapid equilibrium between serum lipoproteins and red cells. The level of red cell cholesterol is influenced by bile salts, which shift the serum/cell partition of free cholesterol to the cell phase and which inhibit the cholesterol-esterifying mechanism. During incubation in normal serum possessing an active cholesterol-esterifying mechanism, red cells lose cholesterol and surface area and thereby become more spheroidal and less resistant to osmotic lysis. When exposed to serum from patients with obstructive jaundice or to normal serum with added bile salts, red cells accumulate cholesterol and increase their surface area, thereby acquiring a flattened shape and an increased resistance to osmotic lysis. The described gains and losses of red cell cholesterol and surface area do not involve metabolic injury and occur with no significant change in phospholipid content.
ACESSO AO ARTIGOhttp://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=297231
- THE USE OF VITAMIN K AND BILE SALTS IN THE PREVENTION AND CONTROL OF THE HÆMORRHAGIC DIATHESIS IN OBSTRUCTIVE JAUNDICE: (Preliminary Report)
- The Three Serum Bile Pigments in Obstructive Jaundice and Hepatitis
- Increased cardiac endocrine activity after common bile duct ligation in the rabbit. Atrial endocrine cells in obstructive jaundice.
- SEROLOGICAL DIFFERENTIATION OF OBSTRUCTIVE FROM HEPATOGENOUS JAUNDICE BY FLOCCULATION OF CEPHALIN-CHOLESTEROL EMULSIONS
- BILE PIGMENTS OF JAUNDICE*