Biased Immunoglobulin G (IgG) Subclass Production in a Case of Hyper-IgM Syndrome

AUTOR(ES)

McLean, G. R.

FONTE

American Society for Microbiology

RESUMO

Hyper-immunoglobulin M (IgM) syndrome (HIGM) is a rare heterogeneous primary immune deficiency. We describe a patient with HIGM characterized by skewed production of serum IgG subclasses and normal somatic hypermutation. This case may represent a subgroup of HIGM type 4 that is characterized by a biased switching to the V-region proximal constant regions.

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