Beta-glucan prevents toxic effects of 2,3,7,8-TCDD in terms of oxidative and histopathological damage in heart tissue of rats
AUTOR(ES)
Ciftci, Osman, Duman, Ahmet Sefa, Turkmen, Neşe Basak, Taslıdere, Aslı
FONTE
Braz. J. Pharm. Sci.
DATA DE PUBLICAÇÃO
29/11/2018
RESUMO
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a widespread environmental contaminant which causes severe toxic effects. Despite there is some suggestion concerning with TCDD induced cardiotoxicity such as formation of free radicals, the main mechanism has not been entirely explained. Beta-glucan is known as strong antioxidant matter and can scavenge free radicals. Therefore this study aimed to investigate the protective effects of beta-glucan against TCDD induced cardiotoxicity in rats. In this study, 2-3 months of age and 190-250 g in weight 32 rats were randomly divided into four equal groups (n=8 for each group). Group 1 was control; Group 2 was TCDD group (2 µg/kg/week); group 3 was the beta-glucan group(50 mg/kg/day), and group 4 was TCDD and beta-glucan treatment group. The heart samples were taken from rats after 21 days treatment. The results were shown that Despite TCDD exposure visibly caused to increase (p ≤ 0.001) in TBARS levels, It caused a visible decline in the levels of GSH, CAT, GSH-Px, and SOD. However Beta glucan significantly increased GSH, CAT, GSH-Px, SOD levels and decreased generation of TBARS. Additionally, our histopathological observations were in agreement with the biochemical results. In conclusion, Beta-glucan treatment exhibited protective activity on TCDD induced cardiotoxicity.
Documentos Relacionados
- Simultaneous Determination of 2,3,7,8-TCDD and 2,3,7,8-TCDF in Water Samples by LLE-LTP and HPLC-DAD
- Cause specific mortality and cancer incidence among employees exposed to 2,3,7,8-TCDD after a 1953 reactor accident.
- Toxic effects of 2,3,7,8 tetrachlorodibenzo 1,4 dioxin in laboratory workers.
- Effect of different beta-glucan preparation pretreatments on fortified bread quality
- Enolase antigen, mannan antigen, Cand-Tec antigen, and beta-glucan in patients with candidemia.