Ber-EP4: new monoclonal antibody which distinguishes epithelia from mesothelial.
AUTOR(ES)
Latza, U
RESUMO
A new monoclonal antibody, Ber-EP4, directed against a partially formol resistant epitope on the protein moiety of two 34 kilodalton and 39 kilodalton glycopolypeptides on human epithelial cells is described. Immunostaining of a wide range of normal and neoplastic human tissues and cell lines showed that all carcinomas and all non-neoplastic epithelial cells, except hepatocytes, parietal cells, and apical cell layers in squamous epithelia, homogeneously expressed Ber-EP4 antigen. As Ber-EP4 does not detect any normal or neoplastic non-epithelial cells, this antibody might prove valuable for the differentiation of the following (i) non-epithelial tumours from undifferentiated carcinomas; (ii) hepatocytes from bile duct cells in certain liver diseases; (iii) mesothelial cells from carcinoma cells in lung biopsy specimens; and (iv) reactive mesothelial cells from carcinoma cells in smears of serous effusions.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=502333Documentos Relacionados
- Ber-ACT8: new monoclonal antibody to the mucosa lymphocyte antigen.
- Ber-MAC3: new monoclonal antibody that defines human monocyte/macrophage differentiation antigen.
- A monoclonal antibody which blocks infection with feline immunodeficiency virus identifies a possible non-CD4 receptor.
- Isolation of a monoclonal antibody which blocks vaccinia virus infection.
- A human monoclonal antibody which inhibits the coaggregation activity of Porphyromonas gingivalis.
