Behind the scenes of functional brain imaging: A historical and physiological perspective
AUTOR(ES)
Raichle, Marcus E.
FONTE
The National Academy of Sciences
RESUMO
At the forefront of cognitive neuroscience research in normal humans are the new techniques of functional brain imaging: positron emission tomography and magnetic resonance imaging. The signal used by positron emission tomography is based on the fact that changes in the cellular activity of the brain of normal, awake humans and laboratory animals are accompanied almost invariably by changes in local blood flow. This robust, empirical relationship has fascinated scientists for well over a hundred years. Because the changes in blood flow are accompanied by lesser changes in oxygen consumption, local changes in brain oxygen content occur at the sites of activation and provide the basis for the signal used by magnetic resonance imaging. The biological basis for these signals is now an area of intense research stimulated by the interest in these tools for cognitive neuroscience research.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=33796Documentos Relacionados
- Physiological basis and image processing in functional magnetic resonance imaging: Neuronal and motor activity in brain
- Brain Imaging: Applications in Psychiatry
- Intellectual Functions and the Brain—An Historical Perspective
- Diffusion and Perfusion Magnetic Resonance Imaging: Applications to Functional MRI
- BOOK REVIEWS: Clinical Brain Imaging: Principles and Applications (Contemporary Neurology Series).
