Bacterial Thymidylate Synthase with Intein, Group II Intron, and Distinctive ThyX Motifs

AUTOR(ES)

Liu, Xiang-Qin

FONTE

American Society for Microbiology

RESUMO

The ThyX class of thymidylate synthases was previously characterized by a common ThyX motif, RHRX7S. We report bacterial ThyX sequences having distinctive ThyX motifs, suggesting a more general ThyX motif, R/THRX7-8S. One ThyX sequence has an intein in its ThyX motif that was shown to do protein splicing and a group II intron in its gene, suggesting a hot spot for these self-splicing mobile elements.

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