Bacterial Cellulose/Collagen Hydrogel for Wound Healing
AUTOR(ES)
Moraes, Paula Rodrigues Fontes de Sousa, Saska, Sybele, Barud, Hernane, Lima, Laís Roncalho de, Martins, Virgínia da Conceição Amaro, Plepis, Ana Maria de Guzzi, Ribeiro, Sidney José Lima, Gaspar, Ana Maria Minarelli
FONTE
Mat. Res.
DATA DE PUBLICAÇÃO
05/02/2016
RESUMO
This study compares a wound dressing based on bacterial cellulose/collagen (BC/COL) hydrogel in rat dorsum with commercial collagenase ointment and untreated wound. The hydrogel was characterized by Scanning Electron Microscopy (SEM), Thermogravimetric Analysis (TGA), Fourier transformed - Infrared spectroscopy (FT-IR) and X-ray diffraction (XRD). According to the In vivo test and macroscopic evaluation, BC/COL hydrogel showed a better repair of wounds and promoted statistically significant differences of tissue repair between treatments on the 7th day after surgery. Better quality, quantity and orientation evaluation of collagen fibers (p=0.0001) were observed in the BC/COL hydrogel and collagenase ointment groups in relation to the control group. The BC/COL hydrogel promoted better wound healing than collagenase and the control group, therefore, it can be considered a potential wound dressing for skin regeneration.
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