Aztreonam therapy in experimental meningitis due to Haemophilus influenzae type b and Escherichia coli K1.
AUTOR(ES)
McCracken, G H
RESUMO
The penetration of aztreonam into cerebrospinal fluid was 7 to 15% and 9 to 25%, respectively, in experimental Haemophilus influenzae type b and Escherichia coli K1 meningitis. Aztreonam was effective in reducing the number of organisms in cerebrospinal fluid after single-dose and continuous infusion administration, and the median bactericidal titers in cerebrospinal fluid were 1:32 against both meningeal pathogens.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=180117Documentos Relacionados
- Pharmacokinetics and bacteriological efficacy of ticarcillin-clavulanic acid (timentin) in experimental Escherichia coli K-1 and Haemophilus influenzae type b meningitis.
- Meningitis Due to Haemophilus influenzae Type e
- Pharmacokinetics and antibacterial efficacy of cefpirome (HR 810) in experimental Escherichia coli and Haemophilus influenzae type b meningitis.
- Meningitis due to Haemophilus influenzae type e biotype 4.
- Tumor necrosis factor in mediating experimental Haemophilus influenzae type B meningitis.
