Azathioprine-induced accelerated cutaneous and pulmonary nodulosis in a patient with rheumatoid arthritis

AUTOR(ES)

Kellet, Cristian Vera, Navarrete, Romina Andino, Bombardieri, Sergio González, Manriquez, Juan

FONTE

An. Bras. Dermatol.

DATA DE PUBLICAÇÃO

2015-06

RESUMO

AbstractWe report the case of a 42-year-old female with a 5-year history of rheumatoid arthritis treated with Rituximab and Azathioprine. Three months after the initiation of Azathioprine, the patient started with dry cough and noted the rapid development of multiple subcutaneous nodules on her right leg. CT scan of the chest demonstrates pulmonary nodulosis. Skin biopsy was compatible with rheumatoid nodule. A diagnosis of "accelerated cutaneous and pulmonary nodulosis" was considered. Azathioprine was discontinued and Rituximab was restarted. Two months later, most of the subcutaneous nodules had disappeared. This is the second case report of accelerated rheumatoid nodulosis in association with Azathioprine treatment.

Documentos Relacionados

• Azathioprine-induced pancytopenia in a patient with pompholyx and deficiency of erythrocyte thiopurine methyltransferase
• Bleomycin-induced pulmonary fibrosis in a patient with rheumatoid arthritis. A possible synergistic effect?
• Persistent pulmonary lesion in a patient with rheumatoid arthritis.
• Azathioprine induced fever, chills, rash, and hepatotoxicity in rheumatoid arthritis.
• Azathioprine induced hepatic veno-occlusive disease in rheumatoid arthritis.