Axenomycins, New Cestocidal Antibiotics
AUTOR(ES)
Bruna, C. Della
RESUMO
Axenomycins are a new group of macrolide antibiotics isolated from the fermentation broth of Streptomyces lisandri n.sp. They exhibit anthelmintic activity against tapeworms (Cestoda). Three different fractions, A, B, and D, have been obtained, the most active fraction being axenomycin D. The activities of the axenomycin complex and axenomycin D against Hymenolepis nana in mice, Taenia pisiformis, Dipylidium caninum, and Diphyllobothrium sp. in dogs, and Moniezia expansa, M. benedeni, and Avitellina centripunctata in lambs were studied in experimentally and naturally infected animals. Axenomycins were effective and well tolerated by the oral route. Worm reduction rates after a single oral dose were 90 to 100% with 5 to 10 mg of axenomycin D/kg and 50 to 100% with 20 mg of axenomycin complex/kg.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=444485Documentos Relacionados
- New Antibiotics—Resistance Is Futile
- New directions for macrolide antibiotics: pharmacokinetics and clinical efficacy.
- In vitro susceptibilities of Aeromonas hydrophila against new antibiotics.
- Inoculum effect of new beta-lactam antibiotics on Pseudomonas aeruginosa.
- Bactericidal activities of new beta-lactam antibiotics against Bacteroides fragilis.