Avaliação tardia do estado de saude de pessoas intoxicadas agudamente por agrotoxicos inibidores das colinesterases

AUTOR(ES)
DATA DE PUBLICAÇÃO

2004

RESUMO

Acute intoxication by cholinesterase-mJnõiting pesticide causes substantial morbidity and mortality worldwide. In Brazil and other countries, the Jate efIects to human health due to acute intoxication by pesticides continue not well known, which is a challenge to researchers. The current writing aimed at to evaluate the heahh conditions of 33 individuaIs, 20 men and 13 women, that were exposed to acute intoxication by cholinesterase-inlnõiting pesticide within January 1994 and December 2000, notified at the Intoxication Control Centre from Maringá and that needed hospital treatment. For the study, 36 individuaIs agreed to take part ofthe research. Three ofthem were excluded: two by having psychiatric diseases prior to intoxication and a child with neurologicaI disturb aIso prior to intoxication. As for the time after the intoxication episode, 19 (57,6%) had been intoxicated 6 years before the research, 8 (24,2%) had intoxicated between 9 and 10 years before. Suicide attempt was the main intoxication cause within the group studied (60,6%). As for the profession, 33,3% were agricuhurists. The main age group was young, with ages from 16 to 40 years (66,7%). Organophosphate pesticides caused 20 intoxications (60,6%), and carbamate pesticides caused 13 intoxications (39,7%). The necessity ofICU internment (42,4%) demonstrated the gravity of intoxications. As for the signaIs and symptoms related by individuaIs at the investigation, could have been found headaches (33,3%), insomnia (33,3%), stomach-aches (27,3%), irritability (18,9%) and muscle weakness (15,1%). The incidence ofhyper blood pressure (42,4%) was greater at the study group than at the ordinary population. LaboratoriaI investigation showed that renal function was normal within all individuaIs, and hepatic function, assessed by the blood dosage of aIanine aminotransferase (AST),aspartate aminotransferase (ALT) and gama glutamil transferase (GAMA GT), modified in 30,3% of individuaIs ITomthe group: three patients in two and one in the three enzymes. The neurologicaI exam was normal and four individuaIs presented electroencephalographic modifications. The dosages of blood cholinesterase showed little aherations. From the resuhs of the research, it can be concluded that the protocol applied could not evidence significant changes on the heaIth of patients examined. The hepatic biochemicaI abnormalities and the high incidence of hyper blood pressure suggest the necessity of complimentary studies in order to establish causal nexus

ASSUNTO(S)

intoxicação cholinesterase inhibitors pesticides inibidores da colinesterase intoxication praguicidas

ACESSO AO ARTIGO

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