Avaliação molecular, tomográfica e microscópica dos côndilos após avanço cirúrgico mandibular utilizando fixação rígida e semi-rígida: estudo em minipigs / Histological, molecular and tomographic condyle analisys after mandibular advancement surgery: study in minipigs

AUTOR(ES)
DATA DE PUBLICAÇÃO

2007

RESUMO

This work aimed at elucidating the changes occurring in temporomandibular joint (TMJ) after surgical mandibular advancement with different fixation materials: miniplates (malleable fixation) and bi-cortical screws (rigid fixation). Twelve minipigs (Minipig BR-1) were operated and served as experimental groups; six non-operated age matched animals served as controls. Four months after the surgeries the animals were sacrificed, and all TMJs and sinovial fluid samples were collected. TMJs were histologically prepared after computerized tomography (CT) scanning, which aimed the detection of osteofite, erosion and flattening. The CT scans examination revealed significant alterations of condylesshape (erosion, P=0,0010 and osteophyte, P<0,0001) for group 2 when compared with groups 1 and 3. The presence of a pro-inflammatory marker, interleukine (IL)-6, and an anti-inflammatory marker, IL-10 in sinovial fluid was assessed in ELISA experiments. Although CT revealed a tendency of bone remodelling in the rigid fixation group, the difference was not statistically significant. In the control group, the same levels of IL-6 and IL-10 were observed (83.2 pg/mL and 80.6 pg/mL, respectively), compatible with no signs of inflammation. In the malleable fixation group higher levels of IL-6 in comparison with IL-10 indicated an active inflammatory process (140.0 pg/mL and 95.6 pg/mL, respectively). In contrast, in the rigid fixation group lower levels of IL-6 compared with IL-10 were found (103.5 pg/mL and 138.9 pg/mL, respectively). Rigid fixation evokes more pronounced signs of bone remodelling in TMJ, whereas malleable fixation promotes a more intense inflammatory activity than rigid fixation. Therefore, intrinsic features of rigid fixation seem to transmit a higher impact of postoperative masticatory forces to TMJ as compared with malleable fixation.

ASSUNTO(S)

remodelação óssea osteosynthesis articulação temporomandibular mandibular avancement bone remodeling temporomandibular joint osteossíntese avanço mandibular

ACESSO AO ARTIGO

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