AVALIAÇÃO DOS FATORES SÓCIOECONÔMICOS, AMBIENTAIS E IMUNOLÓGICOS ASSOCIADOS À PATOGÊNESE DA ESQUISTOSSOMOSE MANSÔNICA NA ÁREA ENDÊMICA DE ILHA DAS FLORES, SERGIPE. / EVALUATION OF SOCIOECONOMIC FACTORS, ENVIRONMENTAL AND IMMUNOLOGICAL FACTORS ASSOCIATED WITH THE PATHOGENESIS OF SCHISTOSOMIASIS MANSONI IN THE ENDEMIC AREA ISLAND OF FLOWERS, SERGIPE.
AUTOR(ES)
Fábio Jorge Ramalho de Amorim
FONTE
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia
DATA DE PUBLICAÇÃO
21/06/2011
RESUMO
Schistosomiasis is an important endemic disease worldwide, affecting over 200 million people. The city of Flores Island, Sergipe, is situated 135 km from the capital, North of the State and has 8,598 inhabitants. Has an extensive irrigation area, where there are many species of snails Biomphalaria glabrata and Biomphalaria straminea. The objectives were to evaluate the morbidity of schistosomiasis in an area of high prevalence of disease by parasitologic, clinical and ultrasound examinations and the relation between infection and disease severity with socioeconomic, educational, exposure to surface water sources in the region and the immune response. A survey was conducted clinical, epidemiological and parasitologic in 500 randomly selected individuals. The prevalence of schistosomiasis was 24%, and 65% of these were male. There is an association between male with S. mansoni infection. Thirty tree percent (33.3%) had clinical forms hepatointestinal or hepatosplenic. Patients with a greater degree of contact with water had higher worm burdens, just as patients with hepatosplenic disease had the higher infection intensity (eggs / g stool). Due to the lower number of hepatosplenic patients, for the immunological studies we have selected 20 patients with confirmed hepatosplenic schistosomiasis actively recruited from the Gastro-hepathology ambulatory of the Hospital Universitário of the Universidade Federal de Sergipe. The abdominal ultrasound examination was performed on a sample of 78 subjects from Ilha das Flores with positive parasitological for S. mansoni and in the 20 hepatosplenic patients from the hospital by the method of Niamey. The evaluation of immune response reveled a direct correlation between the concentrations of IL-5 in response to adult worm antigen and the intensity of infection, as well as a tendency for concentrations of IFN-γ to decrease with the increase the intensity of infection. The immunological data also showed, for the first time, the presence of high concentrations of IL-17 in cultured cells of patients with more severe disease. These data reveal the influence of socioeconomic, cultural and immunological factors on severity of infection by S. mansoni.
ASSUNTO(S)
esquistossomose forma hepatoesplênica resposta imune ciencias da saude schistosomiasis form hepatoesplenic immune response
ACESSO AO ARTIGO
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