Avaliação dos efeitos do extrato padronizado de Rhodiola rosea L. na resposta imunohematopoetica de camundongos infectados com Listeria monocytogenes / Evaluation of Rhodiola rosea L. extrat on immunohematopoietic response of Listeria monocytogenes infected mice

AUTOR(ES)
DATA DE PUBLICAÇÃO

2009

RESUMO

In this work, we have investigated the effects of Rhodiola rosea L. extract (ERR) in Listeria monocytogenes infected mice. Our results demonstrated that ERR protects mice from a lethal dose of L. monocytogenes, when administered prophylactically at 100 and 250 mg/kg, for seven consecutive days prior to the infection. In addition, prevention of myelosuppression induced by infection, concomitant to increasing natural killers (NK) cells activity and production of TNF-a, IFN-? and colony-stimulating factors were observed. The results showed that ERR share the ability of regulating positively the hematopoietic and immunological unbalance involved in the initial stages of infection with this pathogen. These effects could be attributed to recovering of the hematopoietic response through the production of IL-1a and IL-6 by stromal cells in the bone marrow microenvironment and the production of colony-stimulating factors at 24 hours of infection, promoting an increase in the number of granulocytes and macrophages progenitors in the bone marrow microenvironment. Moreover, the efficacy of ERR depends on high levels of TNF-a and IFN- ?, increased NK cells activity and polarization to Th1 response. Together, these effects contribute to increasing resistance to L. monocytogenes

ASSUNTO(S)

celulas estromais cytokines stromal cells celulas nk nk cells citocinas listeria monocytogenes hematopoese listeria monocytogenes hematopoiesis

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