Avaliação dos efeitos de um ativo dermocosmetico composto pelos extratos de Pfaffia paniculata e Ptychopetalum olacoides na prevenção e tratamento de desordens periorbitais / Evaluation of a dermocosmetic active composed by Pfaffia paniculata and Ptychopetalum olacoides associated extract in the prevention and treatment of periorbital disorders

AUTOR(ES)

Samara Eberlin

DATA DE PUBLICAÇÃO

2008

RESUMO

Despite the frequency in which occurs, little has been written in scientific literature on the treatment of periorbital disorders (POD). POD are characterized by alterations in color and shape of the upper and lower eyelids, manifested by hyperpigmentation ("dark circles") and puffiness resulted by fat and fluid accumulation. It has been reported that darkening around the eyes is caused by a process of postinflammatory hemodynamic congestion, characterized by melanin and hemoglobin accumulation. The puffiness caused by orbital adipose tissue is due to an overload of triacylglycerol in the adipocyte, probably as a consequence of circulatory disturbance. Another consequence of the inflammatory process is the local edema due to capillary vasodilatation, which is caused by the release of inflammatory mediators. In addition, POD is usually accompanied by local wrinkling formation, due to deterioration of extracellular matrix (ECM), especially provoked by UV radiation exposure. In this work, we have demonstrated the effects of Pfaffia paniculata/Ptychopetalum olacoides-associated compound (PPLAC) as a dermocosmetic active in the clinical improvement of periorbital disorders. The clinical evaluation showed significant improvements in skin hyperchromia, edema and flaccidity in periorbital area. These clinical observations were also confirmed by in vitro studies, which demonstrated anti-inflammatory, antioxidant and lipolytic effects, besides the ability to stimulate ECM compounds production. Our results clearly encourage the use of this compound as an adjuvant to eyecare dermocosmetics products with the purpose to reduce the local bruised appearance and puffiness improvement

ASSUNTO(S)

cosmetic eyes edema cosmeticos pele olhos edema skin hyperpigmentation hiperpigmentação

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