Avaliação do uso do laser e processos fotodinâmicos na estimulação e crescimento celular de osteoblastos. Avaliação fotofísica e fotobiológica na presença e ausência de fármacos fotossensíveis / Evaluation of the use of laser and photodynamic processes in cell growth and stimulation of osteoblasts. Evaluation photophysical and photobiology in the presence and absence of drugs designed

AUTOR(ES)

Daniela Cervelle Zancanela

DATA DE PUBLICAÇÃO

2009

RESUMO

The laser is a source of non ionizing radiation highly concentrated and coherent that in contact with different tissues induce thermal, photochemical and non-linear effects according to the type of the laser. Currently, the laser has been used routinely in many areas of science, as well as in medicine and dentistry. The treatments using laser radiation of low intensity in dentistry are of great interest specially in the areas of surgery bucco-maxillo-facial and dental implants and its being used to stimulate the process of osteogenesis. A promising new treatment in dentistry area involves the photodynamic process and employs a combination of two therapeutic agents: a photosensitizers drug and a low dose of visible light that combined in the presence of oxygen could induce cellular biostimulation. It is an efficient non-invasive method. Evaluate the use of the drug derived system to administrate photosensitizers as phthalocyanine derivatives chlorine-aluminum specifically for the use in treatment and stimulation of the osteogenesis is the main objective of this work. It will be also evaluated the therapeutic potential of the process. In an attempt to obtain better biocompatibility of these drugs it has developed in recent years an additional interest in the development of nanostructured formulations, focused in a highly emerging line of research the Nanobiotechnology. The nanoemulsion formulation was selected to this work. It was showed that the hydrophobic drugs choose for this work maintaining its photophysical and chemical characteristics in this medium applicable to biological tissue.

ASSUNTO(S)

osteogênese. terapia fotodinâmica ftalocianina bioestimulação osteogenesis. biostimulation phthalocyanine photodynamic therapy

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