Avaliação do perfil de quimiocinas e sua correlação com a intensidade do processo inflamatório nas retinocoroidites supostamente toxoplásmicas

AUTOR(ES)
DATA DE PUBLICAÇÃO

2006

RESUMO

Introduction: chemokines are a specific group of cytokines that has an important role in the angiogenesis and in leucocyte migration into the eye during intraocular inflammation. Purpose: to evaluate serum levels of the chemokines CCL2, CCL11, CXCL8, CXCL9 and CXCL10 in patients with presumed acute toxoplasmic retinochoroiditis, compare them to the patients without history of uveitis and to correlate them to ophthalmic findings. Methods: 55 patients with presumed toxoplasmic retinochoroiditis (Uveitis Group) and 40 patients without history of uveitis (Control Group) were selected to this study. Ophthalmic evaluation was made in all patients and included: visual acuity measure (LogMAR), anterior segment biomicroscopy, direct or indirect binocular opthalmoscopy and ocular pressure measure. Blood sample was collected in all patients after the ophthalmic evaluation. The patients of Uveitis Group received specific treatment and after resolution of the inflammatory process, new blood sample was collected in 18 subjects. To evaluate serum concentrations of the chemokines was used ELISA immunoassay. Results: the serum concentration of the CXCL8 chemokine was higher in the Uveitis Group when compared to the Control Group. The presence of retinal vasculitis was one finding in 43.6% to patients of the Uveitis Group and was correlated with a higher serum concentration of CXCL8. There was not correlation between intensity of vitreous opacities and serum concentrations of the chemokines studied. The patients with acute lesions of retinochoroiditis bigger than 2 diameters of optic disc had statistically higher levels of CXCL8. There was one positive correlation between the size of lesion and the levels of CXCL9. There was statistically decrease in the serum levels of CXCL8 after treatment and healing of active retinochoroiditis. Conclusions: levels of CXCL8 are increased in serum of patients with presumed acute toxoplasmic retinochoroiditis and correlates with the presence of retinal vasculitis and major ocular lesions. Levels of CXCL8 decrease with treatment and may be useful for patient follow up.

ASSUNTO(S)

uveite posterior/etiologia decs retina/imunologia decs coriorretinite/etiologia decs toxoplasmose ocular/complicações decs quimiocinas cxc /sangue decs

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