Avaliação de um modelo animal para estudo da infecção pelo vírus da dengue / Evaluation of an animal model for study of dengue virus infection

AUTOR(ES)

Eric Almeida Xavier

DATA DE PUBLICAÇÃO

2010

RESUMO

Dengue is the arbovirus (arthropod-borne viral disease) more widespread in tropical and subtropical countries. According to World Health Organization estimates that more than 100 million cases occur annually worldwide. Based on serologic tests of dengue viruses are classified into four antigenically distinct serotypes (DENV-1, DENV-2, DENV-3 and DENV-4). The infection of humans with any of the four dengue serotypes can lead to the development of three main clinical forms, undifferentiated febrile illness, classic dengue fever (DF) and dengue hemorrhagic fever with or without shock (DHF / DSS). Previous work to use the strain of mice C57black / 6 obtained results as intraperitoneal hemorrhage and injury to the liver of infected animals, so it was of interest to study how it develops the DENV-1 infection in these animals. So the main objective was to study the DENV-1 infection in C57BL / 6 mice inoculated intraperitoneally. We analyzed the presence of DENV-1 in different organs brain, spleen, liver, kidney and serum from animals C57 Black/6 immunologically competent, as previous work by several research groups in the area is controversial results showing that the subsequent detection of DENV would depend on factors such as viral load, type of infected animals and especially the viral strain used. he main conclusions of our work, the C57BL / 6 infected with DENV-1 mochisuki had detectable viral load until the sixteenth day, in addition to thrombocytopenia, increased hematocrit and levels of IL-10, IFN- and TNF - from the seventh day of infection. So the animal C57BL / 6 wild can be used as an experimental model for infection with DENV

ASSUNTO(S)

flavivirus flavivirus adaptation of dengue type 1 (denv-1) adaptação do dengue tipo 1 (denv-1) virulence cineti aumento da virulência cinética da virulência improves virulence

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