Avaliação de proteção celular a isquemia de retalhos musculares com soluções preservadoras de tecidos em modelo de ratos / Avaliação de proteção celular à isquemia de retalhos musculares com soluções preservadoras de tecidos em modelo de ratos

AUTOR(ES)
DATA DE PUBLICAÇÃO

2009

RESUMO

The free flaps transfer and reimplantation of tissue has in common the exposure of the tissue to ischemia and different time of reperfusion which are important for the determination of the extent of the cellular injury, being sometimes irreversible. In the pre and trans-surgical procedure the control of the ischemic period is difficult. Although efforts are made to prevent and decrease cellular changes using preservative solution, such as University of Wisconsin (UW) used in routine transplant of organs. The availability and high cost of this solution some time is one problem. The present study was made in a rat model that we have been reported in others works, we proposed the utilization of a preservation solution that we called Plastic Surgery-USP solution (PS-USP); witch can be easily prepared with accessible and low cost drugs. The efficiency of this PS-USP solution was compared to UW; our result showed that there is not significative difference in the protective effects of the PS-USP and UW solutions; both solutions were efficient considering cellular protection to ischemia/reperfusion injury, decreasing the risks of flap lost, with low cost and easy disposition

ASSUNTO(S)

apoptosis músculo esquelético skeletal muscle ischemia-reperfusion retalho livre free flap microcirurgia vascular apoptose microsurgery isquemia-reperfusão

ACESSO AO ARTIGO

Documentos Relacionados