Avaliação de extratos de plantas da região amazônica quanto à atividade inibitória da tirosinase / Evaluation of extracts made from Amazon Forest plants and their Tyrosinase inhibitory activity

AUTOR(ES)
DATA DE PUBLICAÇÃO

2004

RESUMO

Dermatological disorders related to pigmentation result in cutaneous hyperpigmentation or hipopigmentation. Cosmetic and pharmaceutical products with despigmentant activity are used for the treatment of patients who have hyperpigmentation disorders. Nowadays, skin whitening agents are not to tally effective and safe, reason for intense researches in order to obtain new agents with action especially ones which inhibit enzymes involved in melanogenesis like tirosinase, mainly in Asian countries. Since some substances from plants have this activity, the flora of Brazil is a potential source of new skin whitening agents. In this study 24 aqueous extracts and 23 organic ones of plants from Amazonian region, and 1 aqueous extracts and 1 organic extract from Atlantic Forest were tested to inhibition of tirosinase using enzymatic method with photometric reader. Out of the 49 tested extracts, 9 showed activity in the screening. These extracts were tested again and 50% tyrosinase inhibitory activity concentration (IA 50%) was calculated. The most activite of them was the organic extract of Ruprechtia sp with IA 50% 33,76µg/mL and the organic extract of Rapanea parviflora with IA 50% 64,19µg/mL.

ASSUNTO(S)

cosméticos doenças da pele e do tecido conjuntivo (tratamento) droga vegetal (avaliação) cosmetics pigmentação pele tyrosinase inhibitor skin plantas farmacobotânica produtos naturais (aplicações terapêuticas) plants pigmentation inibidor de tirosinase

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