Avaliação das subpopulações de linfócitos T CD4+, linfócitos T CD8+ e da razão CD4+/CD8+ em gatos com gengivite crônica e infectados naturalmente pelo vírus da imunodeficiência dos felinos (FIV) / Evaluation of CD4+ and CD8+ T-Lymphocytes count and CD4+:CD8+ ratio in cats with chronic gingivitis and naturally-infected with feline immunodeficiency virus (FIV)

AUTOR(ES)
DATA DE PUBLICAÇÃO

2006

RESUMO

Chronic and intractable gingivitis in FIV-infected cats is a relatively common clinical problem in veterinary practice. The role of FIV in the etiology of persistent stomatitis is still undetermined. Oral manifestations often found in HIV-infected people are frequently the first clinical sign of the infection and can be considered as an indicator of the progression of the HIV infection. The purpose of this study was to evaluate the CD4+ and CD8+ T-lymphocytes count and CD4+:CD8+ ratio in a colony of cats with chronic gingivitis. To achieve these goals, a colony of twenty domestic shorthair cats was used. All cats had some degree of gingival inflammation with scores ranging from 1 through 4. Ten cats were FIV-positive and ten were FIV-negative. As a control, twenty cats without gingivitis were used (ten cats were FIV-positive and ten were FIV-negative). CD4+ and CD8+ T-lymphocytes counts were performed by means of flow cytometry in all forty cats and results compared. The results showed that cats with gingivitis and FIV-infected had a lower CD4+ T cells count than cats with gingivitis but not FIV-infected. There was no difference in CD8+ T lymphocytes count among the cats with gingivitis infected or not with the FIV. The CD4+:CD8+ ratio was lower in cats with gingivitis and FIV-infected. One can conclude that FIV infection induces immunological disorders in cats with gingival inflammation.

ASSUNTO(S)

gingivitis linfócitos lymphocytes feline immunodeficiency virus gengivite vírus da imunodeficiência dos felinos

ACESSO AO ARTIGO

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