Avaliação da imuno-expressão da granzima B na neoplasia intra-epitelial cervical em mulheres infectadas pelo HIV / Evaluation of Granzyme B expression in cervical intraepithelial neoplasia from HIV infected women

AUTOR(ES)
DATA DE PUBLICAÇÃO

2006

RESUMO

Granzyme B is a serine protease synthesized in activated cytotoxic T lymphocyte after exogenous stimulation. Cytotoxic T lymphocyte are the main effector in eradication process of neoplasic cell and virus infected cell. With perforin, granzyme B discharge apoptosis signal to a target cell. The objective of this study was to evaluate granzyme B expression in lymphocytes by immunohistochemistry staining of cervical intraepithelial neoplasia (CIN) in HIV-infected women. A total of 71 pacients have participated of this study: 36 HIV-positive and 35 controls. The majority of HIV-infected women group received highly antiretroviral therapy (HAART) and presented CD4-cell count >200/mm. The activated cytotoxic T lymphocyte mean value in 20 fields (HPF400X), in both epithelials and stromals pars from HIV-positive group and control group were, respectively: without neoplasia (20,5 and 4,6), CIN I (54,0 and 40,3), CIN II and CIN III (36,0 and 58,7). There werent significantly difference between CIN from HIV positive patients and controls. Thus, the high incidence and recorrence of CIN from HIV-infected women werent resulting from granzyme B altered expression in lymphocytes.

ASSUNTO(S)

neoplasia intra-epitelial cervical(nic) ciencias da saude hiv cervical intraepithelial neoplasia (cin) granzyme b hiv granzima b

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