AvaliaÃÃo toxicolÃgica prÃ-clÃnica do Ãleo de Carapa guianensis Aublet.

AUTOR(ES)
DATA DE PUBLICAÇÃO

2006

RESUMO

Carapa guianensis (Meliaceae), a typical tree from amazon region, is popularly known as Andiroba. Its seed oil is used as anti-inflammatory, analgesic and insect repellent. Although C. guianensis is largely used by people, there are no studies concerning its toxicity. In this way, the aim of this work was to evaluate the safety of the C. guianensis seed oil (SO) administration in Wistar rats. Acute toxicity tests were accomplished and the sub-chronic administration influence by oral route, at the doses of 0.375, 0.75 and 1.5 g.kg-1, in biochemical, hematological and reproductive parameters were evaluated. The acute toxicology tests showed that at 5 g.kg-1 the SO produced no deaths. The SO administration during 30 days did not alter the biochemical and hematological parameters, except of the alanine aminotransferase (ALT) level, which increased 29,3 Â 5,3% in the highest dose, when compared to the control group. Furthermore, the liver relative mass increased 19.1 Â 3.7 and 33.3 Â 4.2% at the doses of 0.75 e 1.5 g.kg-1, respectively. The female reproductive toxicity tests showed that the SO administration did not modify the reproductive indexes during the organogenesis period (7th to 14th day of pregnancy) and during the total period of pregnancy (1st to 21st day of pregnancy). However, during the total period, an increased motor activity of the offspring whose mothers were treated with the SO 0,375 g.kg-1 was observed. The reproductive performance showed that a 45 days treatment with SO did not induce alterations in the reproductive indexes, reproductive organs relative masses (epididymis, seminal vesicle, vas deferens), testicular sperm count and in the testicle and epididymis histology. In contrast, it was observed, at all tested doses, a significative decrease in testicle relative mass of 15.1 Â 1.7, 21.9 Â 3.7 and 16.7 Â 3.3%, respectively, and it was observed a decrease of 57.3 Â 12.3% in the sperm number in epididymis cauda only at the highest dose. In conclusion, the C. guianensis seed oil treatment showed low toxicity by oral route in rodents. However, the ALT level and liver relative mass increases, the behavioral development alteration and the testicle mass and epididymis sperm number decreases suggets a possible toxicity that must be analyzed with further details

ASSUNTO(S)

meliaceae seed oil Ãleo da semente carapa guianensis aublet toxicology toxicologia farmacia carapa guianensis aublet meliaceae

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