AvaliaÃÃo do polimorfismo da lectina ligadora de manose (MBL-2) na patogÃnese do lÃquen plano oral

AUTOR(ES)
DATA DE PUBLICAÇÃO

2008

RESUMO

Background: Current evidence suggests that the etiopathogenesis of oral lichen planus (OLP) is a T cells mediated process possibly associated with tumor necrosis factor alpha. Mannose-binding lectin is a multimer protein responsible for the activation of the complement system. It has been suggested that low levels of MBL, possibly associated with its polymorphism, may increase in vitro production of TNF-α. The aim of this study was to evaluate the MBL-2 polymorphisms in OLP pathogenesis. Methods: The sample comprised individuals distributed into a group of individuals with OLP (n = 45) and a group of healthy volunteers (n = 45), (mean age 43 years; range 18-67). MBL-2 gene was amplified through a real-time PCR. For the statistical analysis Mann-Whitney, Fisher s exact test and Likelihood Ratio were used. Results: Data showed that genotype frequencies A/A was 55.6% in OLP patients and 53.3% in healthy subjects. For the heterozygote genotype A/0 42.2% were carriers of OLP and 35.6% healthy subjects. 2.2% and 11.1%, respectively, showed the homozigous mutant 0/0. The allele frequencies "A" and "0" were 77% and 23% in OLP group and 71.2% and 28.8% in the control, respectively. There was no statistically significant difference in genotype frequencies (p = 0.546) or for allelic (p = 0.497). Conclusions: Our findings showed no significant association between MBL-2 gene polymorphisms in oral lichen planus etiopathogenesis.

ASSUNTO(S)

odontologia polymorphisms polimorfismo oral lichen planus lectina ligadora de manose mannose-binding lectin lÃquen plano oral

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