AvaliaÃÃo da influÃncia do percentual de marcaÃÃo do 99mTc-MIBI em procedimentos de medicina nuclear em Recife

AUTOR(ES)
DATA DE PUBLICAÇÃO

2003

RESUMO

The aim of this work was to evaluate the influence of percent labeling of the radiopharmaceutical 99mTc-MIBI on the procedures adopted by the nuclear medicine clinics in Recife, and their possible interference with image quality in myocadial perfusion examinations. This work was performed at two nuclear medicine services in Recife that use pharmaceuticals provided by two different manufacturers: Cardiolite, provided by DUPONT and Cardiosyd, provided by SYDMA. The pH, percent labeling and stability of samples of 99mTc-MIBI and the percent uptake in heart and liver of a number of patients were evaluated. The results showed that the pH values measured in all samples of both radiopharmaceuticals were within the limits recommended. In 48% of the Cardiolite samples, the percent labeling was less than 90%, which is the minimum recommended limit. On the other hand, 87,5% of the Cardiosyd samples measured values above 98%. Both radiopharmaceuticals had good labeling stability, even in samples with low percent labeling efficiencies. In spite of the higher percent labeling of Cardiosyd its heart uptake is similar to that observed with the Cardiolite, even when the percent labeling is lower than 90%. On the other hand, the image quality, according to physicians, evaluation was poorer for Cardiosyd images, due to high noise and poor sharpness

ASSUNTO(S)

99mtc-mibi engenharia nuclear nuclear medicine myocardial perfusion 99mtc-mibi perfusÃo do miocÃrdio medicina nuclear

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