Autorregulação encefálica durante manobra de preensão manual avaliada pela técnica de autorregressão de médias móveis através do Doppler transcraniano / Cerebral hemodynamic changes assessed by transcranial Doppler ultrasonography during handgrip maneuver

AUTOR(ES)
FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

03/08/2012

RESUMO

We investigated the effect of handgrip (HG) maneuver on time-varying estimates of dynamic cerebral autoregulation (CA), using the autoregressive moving average (ARMA) technique. Twelve healthy subjects were recruited to perform HG maneuver during 3 minutes with 30% of maximum contraction force. Cerebral blood flow velocity, end-tidal CO2 pressure (PETCO2), and noninvasive arterial blood pressure (ABP) were continuously recorded during baseline, HG and recovery. Critical closing pressure (CrCP), resistance areaproduct (RAP), and time-varying autoregulation index (ARI) were obtained. PETCO2 did not show significant changes during HG maneuver. Whilst ABP increased continuously during the maneuver, to reach 27% of its baseline value, CBFV raised to a plateau approximately 15% above baseline. This was sustained by a parallel increase in RAP, suggestive of myogenic vasoconstriction, and a reduction in CrCP that could be associated with metabolic vasodilation. The time-varying ARI index dropped at the beginning and end of the maneuver (p<0.005), which could be related to corresponding alert reactions or to different time constants of the myogenic, metabolic and/or neurogenic mechanisms. Changes in dynamic CA during HG suggest a complex interplay of regulatory mechanisms during static exercise that should be considered when assessing the determinants of cerebral blood flow and metabolism

ASSUNTO(S)

autorregulação blood flow brain doppler transcraniana encéfalo fluxo sanguíneo homeostasis ultrasonography doppler transcranial ultrassonografia

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