Autoimmune central diabetes insipidus in a patient with ureaplasma urealyticum infection and review on new triggers of immune response

AUTOR(ES)

Murdaca, Giuseppe, Russo, Rodolfo, Spanò, Francesca, Ferone, Diego, Albertelli, Manuela, Schenone, Angelo, Contatore, Miriam, Guastalla, Andrea, De Bellis, Annamaria, Garibotto, Giacomo, Puppo, Francesco

FONTE

Arch. Endocrinol. Metab.

DATA DE PUBLICAÇÃO

28/08/2015

RESUMO

Diabetes insipidus is a disease in which large volumes of dilute urine (polyuria) are excreted due to vasopressin (AVP) deficiency [central diabetes insipidus (CDI)] or to AVP resistance (nephrogenic diabetes insipidus). In the majority of patients, the occurrence of CDI is related to the destruction or degeneration of neurons of the hypothalamic supraoptic and paraventricular nuclei. The most common and well recognized causes include local inflammatory or autoimmune diseases, vascular disorders, Langerhans cell histiocytosis (LCH), sarcoidosis, tumors such as germinoma/craniopharyngioma or metastases, traumatic brain injuries, intracranial surgery, and midline cerebral and cranial malformations. Here we have the opportunity to describe an unusual case of female patient who developed autoimmune CDI following ureaplasma urealyticum infection and to review the literature on this uncommon feature. Moreover, we also discussed the potential mechanisms by which ureaplasma urealyticum might favor the development of autoimmune CDI.

Documentos Relacionados

• Humoral immune response to polypeptides of Ureaplasma urealyticum in women with postpartum fever.
• Ureaplasma urealyticum causing persistent urethritis in a patient with hypogammaglobulinaemia.
• Clinical and biological characteristics of Ureaplasma urealyticum induced polyarthritis in a patient with common variable hypogammaglobulinaemia.
• Permanent diabetes insipidus in a patient with mesothelioma treated with immunotherapy
• Infection of the epididymis by Ureaplasma urealyticum.