Australia antigen and primary biliary cirrhosis
AUTOR(ES)
MacSween, R. N. M.
RESUMO
Sera from 64 patients with primary biliary cirrhosis have been examined for Australia antigen (Au). On immunodiffusion and immunoelectrophoresis all sera were negative. Using a radioimmunoprecipitation technique 15·6% of sera contained antigen compared with an incidence of 3·1% in matched controls, a significant difference (p = 0·015). Anti-Au was found in 9·4% of patients and in 7·8% of controls. In lymphocyte transformation studies lymphocytes from one of 24 patients with primary biliary cirrhosis transformed on stimulation with an Au-rich serum.
