Attention déficit disorder (ADHD): socialdemographic description and study of candidates genes / "Transtorno de déficit de atenção e hiperatividade no adulto (TDAH): perfil sócio-demográfico e estudo de genes candidatos"

AUTOR(ES)
DATA DE PUBLICAÇÃO

2005

RESUMO

Background: Attention deficit hyperactivity disorder (ADHD) is an early onset neuropsychiatric disorder that affects 2% to 6% of school-age children and into adulthood in as 2/3 of the cases. Symptoms include impulsivity, inattention and hyperactivity. Its pathophysiology is thought to involve the dopaminergic pathway. These symptoms appears in childhood, but the course of the condition and the expression in adulthood is not well characterized yet. Method: This study consists in selecting adults with DSM-IV ADHD. The association between variants of the gene coding for the dopamine transporter (DAT1) and for the dopamine receptor gene subtype4 (DRD4) was also investigated in 102 patients with ADHD and in 481 healthy controls. Results: Our ADHD group presented a predominance of males (61,3%), 86,3% were Caucasians and 90,2% had higher education level (least college level). It was also observed a decreased performance in occupational and academic activities in this group. We found difference of distribution of the DAT1 and DRD4 variant genes between the case and controls. Conclusions: The present report is the first on a Brazilian AHD adult population and the clinical results are quite similar to others observed in other countries in different cultures. In view of previous positive reports in child ADHD, further caractherization of the phenotype is required to clarify the potential role of DAT1 and DRD4 as a risk factor in ADHD.

ASSUNTO(S)

dopamina adult dopamine transtorno da falta de atenÇÃo com hiperatividade/genética estatÍsticas demogrÁficas demographic statistics adulto attention deficit disorder with hyperactivity/genetics

ACESSO AO ARTIGO

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