Atividade inibitoria de extratos vegetais sobre Candida spp e sobre proteinases sintetizados por Candida albicans / Inhitor activity from vegetable extracts in Candida spp and in proteinases synthesize by Candida albicans
AUTOR(ES)
Rita de Cassia Mardegan
DATA DE PUBLICAÇÃO
2007
RESUMO
The use of plants as medicinal substances is one of the most old medicine practices of the humanity. In the last years, the frequency of systemic yeast infection, mainly the opportunistic, has been increased. The overall aims of the present study were: 1 - to test the extract activity (dichloromethane and methanolic) from Rosmarinus officinalis, Mentha piperita, Casearia sylvestris, Arctium lappa, Arrabidaea chica and Tabebuia avellanedae to determine the antifungal activity using strains of Candida spp (C. albicans, C. dubliniensis, C. parapsilosis, C. tropicalis e C. krusei) and in clinical isolates of C. albicans by determination of minimum inhibitory concentration (MIC) and 2 - evaluate the capacity of the extracts to inhibit the activity of proteinases produced by C. albicans, one of the most important virulence factor of these specie. It has been included as a control to evaluate the inhibition of proteolitic activity Amprenavir e Ritonavir and Pepstatina A. Our results showed a variety of MIC patterns according to the strain sensibility. The methanolic extract of Arrabidaea chica was the most effective in inhibiting the growth of a variety of Candida species, including the clinical isolates of C. albicans, followed by dichloromethane extract of Arctium lappa and Mentha piperita. In relation of the proteinases inhibitory tests from C. albicans the most effective extracts tested were dichloromethane of Arrabidaea chica, Casearia sylvestris and Mentha piperita. In conclusion the methanolic extract from A. chica and dichloromethane extracts from A. lappa, M. piperita e C. sylvestris have relevant antifungal activity against a range of Candida specie in vitro and are promising antifungal agents
ASSUNTO(S)
casearia sylvestris rosmarinus officinalis mentha piperita tabebuia avellanedae virulence factors fatores de virulencia arrabidaea chica
ACESSO AO ARTIGO
http://libdigi.unicamp.br/document/?code=000397702Documentos Relacionados
- Atividade inibitória in vitro de extratos de Arrabidaea chica (Verlot.) sobre Candida albicans
- Atividade inibitória de extratos vegetais do cerrado sobre alfa-amilases
- Estudo da composição química e ação inibitória dos extratos obitidos de Punica granatum L. (romã) sobre Candida spp
- Avaliação da atividade antifúngica de extratos vegetais e antissépticos bucais em Candida albicans
- AVALIAÇÃO DA ATIVIDADE ANTIFÚNGICA DE EXTRATOS NATURAIS E PRÓPOLIS SOBRE CANDIDA spp. ESTUDO IN VITRO