Astrocyte elevated gene-1 (AEG-1) is induced by lipopolysaccharide as toll-like receptor 4 (TLR4) ligand and regulates TLR4 signalling

AUTOR(ES)

Khuda, Imtiaz I-E

FONTE

Blackwell Science Inc

RESUMO

Astrocyte elevated gene-1 (AEG-1) is induced by human immunodeficiency virus 1 (HIV-1) infection and involved in tumour progression, migration and invasion as a nuclear factor-κB (NF-κB) -dependent gene. The involvement of AEG-1 on lipopolysaccharide (LPS) -induced proinflammatory cytokine production was examined. AEG-1 was induced via NF-κB activation in LPS-stimulated U937 human promonocytic cells. AEG-1 induced by LPS subsequently regulated NF-κB activation. The prevention of AEG-1 expression inhibited LPS-induced tumour necrosis factor-α and prostaglandin E2 production. The AEG-1 activation was not induced by toll-like receptor ligands other than LPS. Therefore, AEG-1 was suggested to be a LPS-responsive gene and involved in LPS-induced inflammatory response.

Documentos Relacionados

• Toll-like receptor 4 (TLR4) na modulação da imunidade do tipo 2.
• Phylogenetic variation and polymorphism at the Toll-like receptor 4 locus (TLR4)
• Toll-like receptor 4 (TLR-4) regulates renal ion transport
• Associação entre polimorfismos de nucleotídeo único (SNPs) no gene codificador do Toll-like receptor 4 (TLR4) e contagem celular somática
• Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide