Association of HLA-DRB1 alleles with giant cell tumour of bone.

AUTOR(ES)

Varanasi, S S

RESUMO

AIM: To examine the possible influence of the MHC class II antigens alleles in the formation of the multinucleate aggressive giant cell tumour of bone. METHODS: HLA class II antigen alleles were investigated in eight white patients from north east England with confirmed diagnosis of giant cell tumour of bone. All had locally aggressive, immunophenotypically HLA-DR negative giant cell tumours. RESULTS: Five of the eight patients were found to be positive for HLA-DRB1*0801/3, the distribution of this allele in healthy white controls being quite low (2%). All but one of the patients possessing DRB1*080 also expressed DRB1*070. CONCLUSIONS: HLA-DRB1*080 is pre-dominant in patients with immunophenotypic HLA-DR negative giant cell tumour of bone; individuals with the genotype 070/080 are at particularly high risk of developing giant cell tumour of bone.

Documentos Relacionados

• A majority of Brazilian patients with rheumatoid arthritis HLA-DRB1 alleles carry both the HLA-DRB1 shared epitope and anti-citrunillated peptide antibodies
• Specific HLA-DQB and HLA-DRB1 alleles confer susceptibility to pemphigus vulgaris
• Specific HLA-DQB and HLA-DRB1 alleles confer susceptibility to pemphigus vulgaris.
• The association of HLA-DRB1 alleles and drug use with HIV infection in a Chinese Han Cohort
• HLA-DRB1 alleles in four Amerindian populations from Argentina and Paraguay