Association between polymorphisms in the APOB gene and hyperlipidemia in the Chinese Yugur population
AUTOR(ES)
Gu, Q-L., Han, Y., Lan, Y-M., Li, Y., Kou, W., Zhou, Y-S., Hai, X-J., Yan, B., Ci, C-H.
FONTE
Braz J Med Biol Res
DATA DE PUBLICAÇÃO
12/09/2017
RESUMO
We investigated the influence of apolipoprotein B gene (APOB) variants on the risk of hyperlipidemia (HL) in 631 middle-aged and elderly members of the Chinese Yugur population (HL, n=336; normolipidemia, n=295). APOB polymorphisms were identified using mass spectrometry, and five single nucleotide polymorphisms (rs1042034, rs2163204, rs512535, rs676210, and rs679899) and serum lipids were further analyzed. rs1042034 and rs676210 were significantly associated with HL (P<0.05). Compared with the GG or AA genotype, individuals with AG and AG+AA in rs1042034 and with AG and AG+GG in rs676210 had a 1.67-fold (95%CI=1.20–2.33),1.63-fold (95%CI=1.19–2.24), 1.72-fold (95%CI=1.24–2.40), and 1.67-fold (95%CI=1.21–2.291) increased risk of high HL, respectively. rs2163204 was in strong linkage disequilibrium with rs1042034, rs676210, and rs679899, and strong disequilibrium was observed between rs1042034 and rs676210 (D′>0.9). Compared with the GTGAA haplotype, haplotypes ATGGA and ATAGG were more strongly associated with HL [odds ratio (OR)=1.46, 95%CI=0.02–2.11; OR=1.63, 95%CI=1.03–2.60, respectively]. The risk factors age (P=0.008), body mass index (P<0.0001), GA+GG genotype in rs676210 (P=0.009), and alcohol consumption (P=0.056) contributed strongly to HL development. The A allele of rs1042034 and the G allele of rs676210 may thus predispose middle-aged and elderly members of the Chinese Yugur population to HL in combination with other genetic or nutritional factors, and could be used as new genetic markers for HL screening.
Documentos Relacionados
- A lack of association between adiponectin polymorphisms and coronary artery disease in a Chinese population
- Association between MFN2 gene polymorphisms and the risk and prognosis of acute liver failure: a case-control study in a Chinese population
- Association of MDR1 gene polymorphisms with the risk of hepatocellular carcinoma in the Chinese Han population
- Association of PRKAA1 gene polymorphisms with chronic hepatitis B virus infection in Chinese Han population
- Two new ApoB gene polymorphisms: Rs1 and Rs2.