Association between Knops blood group polymorphisms and susceptibility to malaria in an endemic area of the Brazilian Amazon
AUTOR(ES)
Fontes, Aparecida Maria, Kashima, Simone, Bonfim-Silva, Ricardo, Azevedo, Rochele, Abraham, Kuruvilla Joseph, Albuquerque, Sérgio Roberto Lopes, Bordin, José Orlando, Langhi Júnior, Dante Mário, Covas, Dimas Tadeu
FONTE
Genetics and Molecular Biology
DATA DE PUBLICAÇÃO
28/10/2011
RESUMO
Complement receptor 1 (CR1) gene polymorphisms that are associated with Knops blood group antigens may influence the binding of Plasmodium parasites to erythrocytes, thereby affecting susceptibility to malaria. The aim of this study was to evaluate the genotype and allele and haplotype frequencies of single-nucleotide polymorphisms (SNPs) of Knops blood group antigens and examine their association with susceptibility to malaria in an endemic area of Brazil. One hundred and twenty-six individuals from the Brazilian Amazon were studied. The CR1-genomic fragment was amplified by PCR and six SNPs and haplotypes were identified after DNA sequence analysis. Allele and haplotype frequencies revealed that the Kn b allele and H8 haplotype were possibly associated with susceptibility to Plasmodium falciparum. The odds ratios were reasonably high, suggesting a potentially important association between two Knops blood antigens (Kn b and KAM+) that confer susceptibility to P. falciparum in individuals from the Brazilian Amazon.
Documentos Relacionados
- Anopheles darlingi and Anopheles marajoara (Diptera: Culicidae) susceptibility to pyrethroids in an endemic area of the Brazilian Amazon
- Evidence of an association between the O blood group and allergic rhinitis
- Association of Blood-Group and Protein Polymorphisms with Embryonic Mortality in the Chicken
- Normative evaluation of blood banks in the Brazilian Amazon region in respect to the prevention of transfusion-transmitted malaria
- Testing the association between thyroid dysfunction and psychiatric diagnostic group in an iodine-deficient area
