Association between calcitonin receptor gene polymorphisms and calcium stone urolithiasis: A meta-analysis
AUTOR(ES)
Xing, Jinchun
FONTE
Int. braz j urol.
DATA DE PUBLICAÇÃO
07/11/2019
RESUMO
ABSTRACT Purpose It has been reported that calcitonin receptor (CALCR) gene polymorphisms might be associated with calcium stone urolithiasis. Owing to mixed and inconclusive results, we conducted a meta-analysis to summarize and clarify this association. Materials and Methods A systematic search of studies on the association between CALCR gene polymorphisms and calcium stone urolithiasis susceptibility was conducted in databases. Results Odds ratios and 95% confidence intervals were used to pool the effect size. Five articles were included in our meta-analysis. Conclusions CALCR rs1801197 might be associated with increased risk of calcium stone urolithiasis. There is insufficient data to fully confirm the association between CALCR rs1042138 and calcium stone urolithiasis susceptibility. Well-designed studies with larger sample size and more subgroups are required to validate the risk identified in the current meta-analysis.
Documentos Relacionados
- Evaluation of the association between KIR polymorphisms and systemic sclerosis: a meta-analysis
- Association between hormone replacement therapy and subsequent stroke: a meta-analysis
- The association between body mass index and varicocele: A meta-analysis
- Association between tumor necrosis factor polymorphisms and rheumatoid arthritis as well as systemic lupus erythematosus: a meta-analysis
- Association between metabolic syndrome and periodontitis: a systematic review and meta-analysis