Associação entre fatores ambientais de exposição ao chumbo e plumbemia com abortamento espontaneo

AUTOR(ES)
DATA DE PUBLICAÇÃO

2004

RESUMO

The objective of this study was to evaluate the association between environmental risk factors and blood lead levels with the occurrence of spontaneous abortion in pregnant who were assisted in the period from February 2003 to July 2004 at Maternity Hospital Leonor Mendes de Barros, in São Paulo. The study had two designs: case-control study to evaluate environmental risk factors of exposition to the lead and cross section, which evaluated the blood lead level of population who had been studied. It has evaluated 190 women with spontaneous abortion (cases) and 190 women with alive fetus (controls), who accepted to participate of this study. The subjects were interviewed using a specific questionary prepared for this study and submitted a blood sample in order to determine the blood lead level. They were analyzed variables such as: social-demographics, environmental, occupational, behaviour and chemical addictions related to lead exposure as well obstetrical history and the blood lead level. Blood lead determinations were carried out using atomic absorption spectrophotometry. Statistical analysis included mean determination and standard deviation for continuous numerical variables, Mann-Whitney and Wilcoxon non-parametric tests, Odds Ratio plus its correspondent 95% CI to identify the association between factors of exposition to the lead and abortion, and multivariate analysis. Among environmental factors related to lead exposure, just the consumption of canned food [OR=3.80 (IC95%=1.38-12.20)] and paid work [OR=2.52 (IC95%=1.29-5.28)] were associated to the abortion. The mean blood lead level was 2.71µg/dl to cases group and 2.39µg/dl to controls group without significant statistically difference. We concluded that did not have significant influence of environmental factors related to lead exposure studied and the blood lead level was not different among women with or without abortion. The mean blood lead level in the third quarter in pregnant not professionally exposed were 2.24µg/dl, this value could be used as reference in a studies involving determination to blood lead in the pregnancy

ASSUNTO(S)

gravidez morte fetal metais pesados riscos ambientais

ACESSO AO ARTIGO

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