Associação do HLA-B*14 e HLA-Cw*08 com a suscetibilidade para vasculite reumatóide (VR) e HLA-DRB5*01 na proteção para VR em pacientes brasileiros / Association of HLA-B*14 and HLA-Cw*08 with susceptibility to rheumatoid vasculitis (RV) and HLA-DRB5*01 with protection against RV in brazilian patients

AUTOR(ES)
FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

31/08/2010

RESUMO

Our purpose was to evaluate the frequency and clinical association of HLA class I and class II in Brazilian patients with rheumatoid vasculitis (RV). We evaluated 57 patients with rheumatoid arthritis (RA) (American College of Rheumatology -ACR, 1987 criteria). Seventeen had RV according to Scott and Bacon s criteria - 1984. Demographic data, time of RA diagnosis, disease activity by the Disease Activity Score (DAS 28), rheumatoid factor (RF) and cyclic citrullinated peptide (anti-CCP) were analyzed. HLA alleles were typed using polymerase chain reaction-amplified DNA hybridized with low-resolution sequence-specific primers. HLA-B*15 (p=0.033) and HLA-DRB1*01 (p=0.014) were associated with moderate activity of RA without RV, and HLA-B*07 (p=0.027) and HLA-Cw*16 (p=0.027) with intense activity of RA without RV; no statistical significance of HLA class and DAS 28 was observed in RV. HLA-DQB1*05 (p=0.035) was related to RV in patients with late RA. The comparison between the groups showed an increased frequency of HLA-B*14 (p = 0.006) and HLA-Cw*08 (p = 0.006) in patients with RV, and an increased frequency of HLADRB5* 01 (p = 0.048) in patients without RV. In conclusion, the HLA-B*14 and HLACw* 08 may be involved in susceptibility to RV and HLA-DRB5*01 may confer protection against this extra articular manifestation of RA

ASSUNTO(S)

vasculite reumatóide antigenos hla auto-imunidade rheumatoid vasculitis antigen hla autoimmunity

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