Aspectos epidemiológicos, morfológicos e terapêuticos do linfoma cutâneo e índices de proliferação celular (PCNA e Ki-67) no linforma multicêntrico em cães

AUTOR(ES)
DATA DE PUBLICAÇÃO

2008

RESUMO

Lymphomas are a diverse group of malignant neoplasms that originate in lymphoid tissues. Several classification systems were established to enhance the understanding of the biological behavior of this disease in both human and veterinary medicine. The anatomical classification developed by World Health Organization (WHO) is the most simple and it is based in the primary site of appearance. The pattern of growth, immunophenotypic features and mitotic rates consist the main basis to understand the tumor behavior, determining prognosis, and influencing treatment selection. In this study the epidemiologic, morphologic and therapeutic aspects of 49 dogs with cutaneous lymphoma were evaluated. The association between the malignant grade, immunophenotyping, and cellular proliferation (PCNA and Ki-67) were also evaluated in 55 dogs with the multicentric form. Within cutaneous lymphoma, 35 dogs were females and 14 were males, many different breeds were represented but more frequently in pure breeds and age from 2 to 14 years. This tumor was more frequent in small and medium breeds, with lesions in abdomen, dorsum and trunk. The morphologic classification was made in 21 dogs, with twelve non epiteliotrophic and nine epiteliotrophic form. In the majority of the cases the multiple-drug therapy was established, and the remission was complete. The single-drug therapy result in stable or progressive disease, except for patients treated with lomustine. The survival was longerin patients treated with multiple-drugs therapy. In 55 multicentric form dogs were 30 males and 25 females, 39 pure breed and 16 mixed breeds. The mean age was 5.4 years. High malignant grade were 70.1% of cases and low malignant grade represented 29.9%, 32 T cell lymphoma and 23 B cell lymphoma. The mean mitotic cell rate by PCNA antibody were 90,0 ± 3,96 in high malignant grade lymphomas and 82,0 ± 2,60 in low malignant grade concerning all marked cells was no significant difference (p<0,05). When only highly marked cells were counted, mean index was 84,72 ± 3,79 in high grade lymphomas and 64,19 ± 3,50 in low grade lymphomas (p<0,05). The Ki-67 cellular proliferation index was 64,0 ± 9,03 within high malignant grade and 9,50 ± 2,49 within low grade (p=0,0045). There was no association with cellular proliferation of both antibodies and the phenotype.

ASSUNTO(S)

cão - doenças - epidemiologia animais domésticos - doenças câncer em cão linfoma canino dog diseases epidemiology veterinary diseases cancer in dogs

ACESSO AO ARTIGO

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