Artemisia arborescens L essential oil loaded beads: Preparation and characterization
AUTOR(ES)
Lai, Francesco
FONTE
Springer-Verlag
RESUMO
The purpose of this work was to prepare sodium alginate beads as a device for the controlled release of essential oil for oral administration as an antiviral agent. Different formulations were prepared with sodium alginate as a natural polymer and calcium chloride or glutaraldehyde as a cross-linking agent. Loading capacities of between 86% and 100% were obtained in freshly prepared beads by changing exposure time to the cross-linking agent. Drying of the calcium alginate beads caused only a slight decrease in the loading efficiency. The surface morphology of the different bead formulations were studied using scanning electron microscopy (SEM). Stability studies over a 3-month period showed that glutaraldehyde reacted with some components ofArtemisia arborescens L essential oil, changing its composition. Calcium alginate beads showed an in vitro controlled release of the essential oil for the investigated 24 hours, while the use of glutaraldehyde as a cross-linking agent was found not appropriate because of the interactions with azulene derivatives and the low degree of matrix cross-linkage.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2750564Documentos Relacionados
- Artemisia arborescens L essential oil-loaded solid lipid nanoparticles for potential agricultural application: Preparation and characterization
- Preparation of mupirocin-loaded polymeric nanocapsules using essential oil of rosemary
- Preparation and characterization of paclitaxel-loaded PLDLA microspheres
- Analgesic and antiinflammatory activities of the essential oil from Artemisia sieberi Besser
- Preparation and characterization of flurbiprofen beads by melt solidification technique
