Are lipid disorders involved in the predominance of human T-lymphotropic virus-1 infections in women?

AUTOR(ES)

Carvalho, Luciana Debortoli de, Gadelha, Sandra Rocha, Marin, Lauro Juliano, Brito-Melo, Gustavo Eustaquio Alvim, Martins, Camila Pacheco Silveira, Fonseca, Flavio Guimarães da, Barbosa-Stancioli, Edel Figueiredo

FONTE

Rev. Soc. Bras. Med. Trop.

DATA DE PUBLICAÇÃO

2015-12

RESUMO

Abstract INTRODUCTION : The human T-lymphotropic virus-1 (HTLV-1) is associated with chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), a chronic inflammatory disease. Disturbances in lipid metabolism are involved in inflammatory and demyelinating diseases. METHODS : Plasma levels of triglycerides, total cholesterol, and fractions of HTLV-1-infected individuals of both sexes with different clinical progressions were determined. RESULTS : Elevated levels of triglyceride and very low-density lipoproteins (VLDL) were exclusively detected in HTLV-1-infected women from asymptomatic and HAM/TSP groups compared with uninfected individuals (p = 0.02). CONCLUSIONS : Elevated triglyceride and VLDL levels in HTLV-1-infected women may be related to the predominance of HAM/TSP in women.

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