Apparent dependence of sporulation on synthesis of highly phosphorylated nucleotides in Bacillus subtilis
AUTOR(ES)
Rhaese, H. J.
RESUMO
Bacillus subtilis contains an enzyme that synthesizes the highly phosphorylated nucleotide adenosine 5′,3′(2′)-bis(triphosphate), abbreviated p3Ap3. This enzyme can be demonstrated to be present in the cytoplasmic membrane of B. subtilis at all stages of growth and development. During vegetative growth its enzymatic activity is inhibited by phosphorylated metabolites of energy-rich carbon sources, as was shown with the aid of conditional sporulation mutants. The finding that a temperature-sensitive sporulation mutant with a mutation in the spoOF gene, an early sporulation gene, shows a temperature-sensitive activity of p3Ap3-synthetase indicates that p3Ap3 plays an important role in sporulation, probably initiation of sporulation.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=383069Documentos Relacionados
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