Apoptosis and p53 expression in rat adjuvant arthritis
Tak, Paul P
The kinetics of apoptosis and the apoptosis-regulating gene p53 in adjuvant arthritis (AA) were investigated to assess the value of the AA rat model for testing apoptosis-inducing therapies. Very few terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate (dUTP) nick end-labeling (TUNEL)-positive cells were detected during the early phases of AA, but on day 23 (chronic arthritis) the percentage of TUNEL-positive cells was significantly increased. Expression of p53 in synovial tissue gradually increased from days 5-23, which was markedly higher than p53 levels in rheumatoid arthritis (RA) synovium. Significant apoptosis only occurs late in rat AA and is concordant with marked p53 overexpression, making it useful model for testing proapoptotic therapies, but rat AA is not the best model for p53 gene therapy because dramatic p53 overexpression occurs in the latter stages of the disease.
ACESSO AO ARTIGOhttp://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=17810
- p53 and the hypoxia-induced apoptosis of cultured neonatal rat cardiac myocytes.
- Baculovirus p33 Binds Human p53 and Enhances p53-Mediated Apoptosis
- p53 in rheumatoid arthritis: friend or foe?
- Nucleophosmin Blocks Mitochondrial Localization of p53 and Apoptosis*
- E2F1 Induces Phosphorylation of p53 That Is Coincident with p53 Accumulation and Apoptosis