Antiulcer effect of epoxy-carvone
AUTOR(ES)
Siqueira, Bruna P. J., Menezes, Crislaine T., Silva, Jaciara P., Sousa, Damião P. de, Batista, Josemar S.
FONTE
Revista Brasileira de Farmacognosia
DATA DE PUBLICAÇÃO
23/09/2011
RESUMO
Epoxy-carvone is a monoterpene present in essential oils of various plants. It is a derivative of carvone, which has an epoxy group instead of the α- and β-unsaturated ketone group present in carvone. As recent studies have shown that several alcohol terpenes and compounds containing α, β-unsaturated ketone groups present antiulcer effect, the main of the present study was to evaluate the antiulcer effect of epoxy-carvone. The models of ulcers induced by ethanol and indomethacin were used in this study. Epoxy-carvone at the dose of 1 mg/kg did not present antiulcer effect against ulcer induced by ethanol, but at the doses of 10, 30 and 50 mg/kg it presented gastroprotective effect in both ulcer models. Epoxy-carvone also did not affect the gastric secretion in the pylorus ligation test. Moreover, pretreatment with indomethacin or L-nitroarginine methyl ester did not reverse the gastroprotection produced by this monoterpene. This study showed that epoxy-carvone presents antiulcer effect and suggests that this effect does not involve either antisecretory activity or increase of the nitric oxide and prostaglandin synthesis.
Documentos Relacionados
- Study of antinociceptive and antiinflammatory monoterpene a,b-epoxy-carvone and its effect on glutamatergic neurotransmission.
- Effect of Rebamipide, a Novel Antiulcer Agent, on Helicobacter pylori Adhesion to Gastric Epithelial Cells
- The effect of acetone addition on the properties of epoxy
- The effect of acetone addition on the properties of epoxy
- Effect of the hardener to epoxy monomer ratio on the water absorption behavior of the DGEBA/TETA epoxy system